epilepsy is a neurological disease of the central nervous system. it is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. in the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the dis...

how to cite this article: tavasoli ar, gharib b, alizadeh h, farshadmoghaddam h, memarian s, ashrafi mr, sharifzade m. brain on fires: super refractory seizure in a 7 year old boy. iran j child neurol. autumn 2016; 10(4):80-85. abstract we present a 7 year old boy afflicted with super-refractory seizure that responded poorly to antiepileptic drugs and sustained a long course of hospitalization ...

biotin is a water-soluble vitamin and co-factor for activation of carboxylases apoenzymes. biotinidase enzyme is essential for release of biotin from apoenzymes. absence of biotinidase is an autosomal recessive trait with a prevalence of 1 in 60000. clinical manifestations of biotinidase deficiency include dermatitis, alopecia, seizures, hypotonia, developmental delay, hearing loss, visual impa...

introduction: refractory status epilepticus is a life-threatening disease in children wherein seizure movements don't response to first line anti convulsion drugs. this study reviewed risk factors, management and early outcome of children with refractory status epilepticus. methods: patients with refractory status epilepticus admitted in tabriz children's hospital between 2003 and 200...

background: the main purpose of the current study was to determine the effect of treating helicobacter pylori (hp) infection on seizure frequency in patients with refractory epilepsy. methods: a small sample of adult patients above 18 years of age with a diagnosis of refractory epilepsy was studied at the outpatient epilepsy clinic at shiraz university of medical sciences, from january 2009 thr...

objective 1-3% of the population suffer from epilepsy. up to 30% of them develop refractory epilepsy and their seizures occur more than once per month despite receiving at least 2 first line antiepileptic drugs. in  this group, more efficacious antiepileptics are needed. this study was undertaken to evaluate the efficacy and safety of oxcarbazepine as an adjunction therapy in children with refr...

BACKGROUND Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease. METHODS A retrospective chart review of all patients with TSC seen between January 2002 and October 2008. Charts were reviewed for a history of infantile spasms (IS), seizure other than IS, refractory epilepsy, Lennox-Gastaut ...

Background: Refractory (intractable/pharmaco-resistant) epilepsy in children is considered if disabling seizures continue despite appropriate trials of two anti-seizure drugs, either alone or combination. Ketogenic diets are used as a treatment option many countries for with refractory seizures; however, few patients have tried it Saudi Arabia. Therefore, we examined the relationship between ex...